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Highlights: Retatrutide helped participants lose up to 30% of their body weight , around 85 pounds The drug mimics both GLP-1 and glucagon , making it a triple agonist Retatrutide showed stronger weight reduction than Wegovy and Zepbound in longer trials helped participants lose up to 30 percent of their body weight during clinical trials (1 Trusted Source Lilly's triple agonist, retatrutide, delivered powerful weight loss in pivotal Phase 3 obesity trial Go to source)